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Cracking the code of skin inflammation with CD1a

CD1a on Langerhans cells in the epidermis is the lipid receptor for the plant-derived allergen urushiol and self lipids and is a key amplifier of inflammatory responses in urushiol-induced contact...

Dances with cytokines, featuring TFH cells, IL-21, IL-4 and B cells

Follicular helper T cells (TFH cells) sequentially acquire the potential to secrete interleukin 21 (IL-21) and IL-4. The shift from secretion of IL-21 to that of IL-4 modifies the nature of the 'help'...