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Nature ImmunologySubscribe to this RSS Feed

The balance between protective and pathogenic immune responses in the TB-infected lung

Mycobacterial tuberculosis remains a disease of major importance. In this Focus Review, Orme, Robinson and Cooper discuss lung immune responses to mycobacteria and describe how the bacterium can...

Stop the executioners

Virus-triggered type I interferon induces the lysine methyltransferase Setdb2; this then generates repressive histone marks on the promoters of genes encoding molecules important for antibacterial...

Antiviral B cell and T cell immunity in the lungs

The lungs are the main site of entry for most viral pathogens. In this Focus Review, Chiu and Openshaw discuss adaptive immune responses to lung-tropic viruses and implications for vaccine...

A surprising role for TLR7

Ligation of the Toll-like receptor TLR7 in human CD4+ T cells elicits an anergic state that may contribute to CD4+ T cell hyporesponsiveness after infection with human immunodeficiency virus type 1...