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Nature ImmunologySubscribe to this RSS Feed

Serine-threonine kinases in TCR signaling

TCR engagement triggers activation of downstream kinases. Navarro and Cantrell discuss how the network of serine/threonine kinases instruct T cell metabolism to participate in immune responses.

Integrative biology of T cell activation

TCR ligation activates multiple downstream pathways that lead to myriad functional outputs. Malissen and colleagues discuss how unbiased mass spectrometry using signaling hub 'bait' molecules, such as...

Insights into the initiation of TCR signaling

How agonist peptides initiate the T cell antigen receptor (TCR) signaling cascade is widely debated. Weiss and Chakraborty discuss current models of the proximal signaling events that ensue upon...